KLHL20 Antibody, HRP conjugated
Product Sizes
50 ug
£186.00
CSB-PA22879B0RB-50UG
100 ug
£334.00
CSB-PA22879B0RB-100UG
About this Product
- SKU:
- CSB-PA22879B0RB
- Additional Names:
- Kelch like ECT2 interacting protein antibody; Kelch like protein 20 antibody; Kelch like protein X antibody; Kelch motif containing protein antibody; Kelch-like ECT2-interacting protein antibody; Kelch-like protein 20 antibody; Kelch-like protein X antibody; KHLHX antibody; KLEIP antibody; KLH20_HUMAN antibody; KLHL20 antibody; KLHLX antibody; RP3-383J4.3 antibody
- Application:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Clonality:
- Polyclonal
- Conjugate:
- HRP
- Extra Details:
- Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Kelch-like protein 20 protein (1-200AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:KLHL20-Antibody-HRP-conjugated-12919601.html
