CCNC (Ab-275) Antibody
Product Sizes
100 ul
£332.00
CSB-PA182650-100UL
About this Product
- SKU:
- CSB-PA182650
- Additional Names:
- ccnc antibody; CCNC_HUMAN antibody; CycC antibody; Cyclin C antibody; Cyclin-C antibody; hSRB11 antibody; OTTHUMP00000016897 antibody; SRB11 homolog antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Lew D.J., Cell 66:1197-1206(1991). Li H., Genomics 32:253-259(1996). Mungall A.J., Nature 425:805-811(2003).
- Host:
- Rabbit
- Immunogen:
- Synthesized non-phosphopeptide derived from Human Cyclin C around the phosphorylation site of serine 275 (N-G-S(p)-Q-N).
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:CCNC-Ab-275-Antibody-11084455.html
