CD209 Antibody
Product Sizes
100 ul
£332.00
CSB-PA143864-100UL
About this Product
- SKU:
- CSB-PA143864
- Additional Names:
- C type lectin domain family 4 member L antibody; C-type lectin domain family 4 member L antibody; CD 209 antibody; CD209 antibody; CD209 antigen antibody; CD209 antigen-like protein A antibody; CD209 molecule antibody; CD209_HUMAN antibody; Cd209a antibody; CDSIGN antibody; CIRE antibody; CLEC4L antibody; DC SIGN antibody; DC SIGN1 antibody; DC-SIGN antibody; DC-SIGN1 antibody; DCSIGN antibody; Dendritic cell specific ICAM 3 grabbing nonintegrin 1 antibody; Dendritic cell specific ICAM3 grabbing nonintegrin 1 antibody; Dendritic cell-specific ICAM-3-grabbing non-integrin 1 antibody; Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin antibody; Dengue fever; protection against; included antibody; Dentritic Cell Specific ICAM3 Grabbing Nonintegrin antibody; HIV GP120 Binding Protein antibody; MGC129965 antibody; MGC130443 antibody; SIGN-R1 antibody; SIGNR5 antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. Geijtenbeek T.B.H., Kwon D.S., Torensma R., van Vliet S.J. Cell 100:587-597(2000) Geijtenbeek T.B.H., Krooshoop D.J., Bleijs D.A., van Vliet S.J. Nat. Immunol. 1:353-357(2000) Engering A., Geijtenbeek T.B.H., van Vliet S.J., van Kooyk Y.J. Immunol. 168:2118-2126(2002)
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.389~393( E-Q-F-L-S )derived from Human CD209 (DC-SIGN).
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:CD209-Antibody-11083288.html
