APAF1 Antibody
Product Sizes
100 ul
£332.00
CSB-PA109273-100UL
About this Product
- SKU:
- CSB-PA109273
- Additional Names:
- APAF1-interacting protein; APIP; APIP2; CGI-29 protein; MMRP19
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. Keigo Machida, J. Biol. Chem., Apr 2001; 276: 12140 - 12146. Liam O?nnor, Cancer Res., Mar 2000; 60: 1217 - 1220. Zeping Wang, Nucleic Acids Res., Apr 2005; 33: 2248 - 2258 Govindaraj Anumanthan, Cancer Res., Nov 2006; 66: 10824 - 10832.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from Human APAF-1-ALT.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:APAF1-Antibody-11084498.html
