SP100 Antibody
Product Sizes
100 ul
£332.00
CSB-PA102856-100UL
About this Product
- SKU:
- CSB-PA102856
- Additional Names:
- DKFZp686E07254 antibody; FLJ00340 antibody; FLJ34579 antibody; Lysp100b antibody; Nuclear antigen Sp100 antibody; Nuclear autoantigen Sp 100 antibody; Nuclear autoantigen Sp-100 antibody; Nuclear autoantigen Sp100 antibody; Nuclear dot associated Sp100 protein antibody; Nuclear dot-associated Sp100 protein antibody; SP 100 antibody; SP100 antibody; SP100 HMG nuclear autoantigen antibody; SP100 nuclear antigen antibody; SP100_HUMAN antibody; Speckled 100 kDa antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to . Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to . Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. Dent A.L., Blood 88:1423-1426(1996). Seeler J.-S., Proc. Natl. Acad. Sci. U.S.A. 95:7316-7321(1998). Szostecki C., J. Immunol. 145:4338-4347(1990).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from Internal of Human SP100.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:SP100-Antibody-11086075.html
