ISG15 Antibody, Biotin conjugated
Product Sizes
50 ug
£186.00
CSB-PA09744D0RB-50UG
100 ug
£334.00
CSB-PA09744D0RB-100UG
About this Product
- SKU:
- CSB-PA09744D0RB
- Additional Names:
- G1P2 antibody; hUCRP antibody; IFI 15 antibody; IFI15 antibody; Interferon alpha inducible protein antibody; Interferon induced protein 15 antibody; Interferon induced protein IFI-15K antibody; Interferon stimulated protein 15 kDa antibody; Interferon; alpha-inducible protein (clone IFI-15K) antibody; Interferon-induced 15 kDa protein antibody; Interferon-induced 17 kDa protein antibody; Interferon-induced 17-kDa/15-kDa protein antibody; IP17 antibody; ISG 15 antibody; ISG15 antibody; ISG15 ubiquitin like modifier antibody; ISG15_HUMAN antibody; Ubiquitin cross-reactive protein antibody; Ubiquitin-like protein ISG15 antibody; UCRP antibody
- Application:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Clonality:
- Polyclonal
- Conjugate:
- Biotin
- Extra Details:
- Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Ref.12 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Ubiquitin-like protein ISG15 protein (2-157AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:ISG15-AntibodyBiotin-conjugated-171971.html
