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Antibodies

CLU Antibody

Product Sizes
50 ug
£186.00
CSB-PA06029A0RB-50UG
100 ug
£334.00
CSB-PA06029A0RB-100UG
About this Product
SKU:
CSB-PA06029A0RB
Additional Names:
40 antibody; AAG 4 antibody; AAG4 antibody; Aging associated protein 4 antibody; Aging-associated gene 4 protein antibody; AI893575 antibody; APO J antibody; Apo-J antibody; APOJ antibody; ApoJalpha antibody; ApoJbeta antibody; Apolipoprotein J antibody; ApolipoproteinJ antibody; CLI antibody; CLU antibody; CLU1 antibody; CLU2 antibody; CLUS_HUMAN antibody; Clusterin alpha chain antibody; Clusterin antibody; Clusterin beta chain antibody; Complement associated protein SP 40 40 antibody; Complement associated protein SP 40 antibody; Complement associated protein SP40 antibody; Complement cytolysis inhibitor a chain antibody; Complement cytolysis inhibitor antibody; Complement cytolysis inhibitor b chain antibody; Complement lysis inhibitor antibody; Complement-associated protein SP-40 antibody; D14Ucla3 antibody; Dimeric acid glycoprotein antibody; Glycoprotein 80 antibody; Glycoprotein III antibody; GP80 antibody; Ku70-binding protein 1 antibody; KUB 1 antibody; KUB1 antibody; MGC24903 antibody; NA1/NA2 antibody; RATTRPM2B antibody; SGP 2 antibody; SGP2 antibody; SP 40 antibody; SP40 antibody; Sugp-2 antibody; Sulfated glycoprotein 2 antibody; Testosterone repressed prostate message 2 antibody; Testosterone-repressed prostate message 2 antibody; TRPM 2 antibody; TRPM-2 antibody; TRPM2 antibody; TRPM2B antibody; Trpmb antibody
Application:
ELISA, Immunofluorescence, Immunohistochemistry
Buffer:
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Clonality:
Polyclonal
Extra Details:
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
Host:
Rabbit
Immunogen:
Recombinant Human Clusterin protein (23-224AA)
Isotype:
IgG
Physical State:
Liquid
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles.
Supplier:
Cusabio
Type:
Antibody: Polyclonal Antibody
Immunofluorescence staining of Hela cells with CSB-PA06029A0Rb at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of CSB-PA06029A0Rb diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA06029A0Rb diluted at 1:200 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.