DDIT4L Antibody
Product Sizes
50 ul
£186.00
CSB-PA049554-50UL
100 ul
£334.00
CSB-PA049554-100UL
About this Product
- SKU:
- CSB-PA049554
- Additional Names:
- DDIT4L antibody; REDD2 antibody; RTP801LDNA damage-inducible transcript 4-like protein antibody; HIF-1 responsive protein RTP801-like antibody; Protein regulated in development and DNA damage response 2 antibody; REDD-2 antibody
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL)-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of Human DDIT4L
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:DDIT4L-Antibody-11101214.html
