IRAK1BP1 Antibody
Product Sizes
50 ul
£186.00
CSB-PA048353-50UL
100 ul
£334.00
CSB-PA048353-100UL
About this Product
- SKU:
- CSB-PA048353
- Additional Names:
- ActA binding protein 3 antibody; AIP70 antibody; IKBP1_HUMAN antibody; Interleukin 1 receptor associated kinase 1 binding protein 1 antibody; Interleukin-1 receptor-associated kinase 1-binding protein 1 antibody; IRAK1-binding protein 1 antibody; IRAK1BP1 antibody; Signaling molecule that associates with Pelle-like kinase antibody; SIMPL antibody
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of Human IRAK1BP1
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:IRAK1BP1-Antibody-11099640.html
