ITGB1 Antibody
Product Sizes
100 ul
£332.00
CSB-PA034125-100UL
About this Product
- SKU:
- CSB-PA034125
- Additional Names:
- beta1 integrin antibody; CD_antigen=CD29 antibody; CD29 antibody; Fibronectin receptor subunit beta antibody; FNRB antibody; Glycoprotein IIa antibody; GP IIa antibody; GPIIA antibody; Integrin beta-1 antibody; Integrin subunit beta 1 antibody; integrin VLA-4 beta subunit antibody; Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) antibody; ITB1_HUMAN antibody; ITGB1 antibody; MDF2 antibody; MSK12 antibody; OTTHUMP00000019420 antibody; very late activation protein antibody; Very late activation protein, beta polypeptide antibody; VLA BETA antibody; VLA-4 subunit beta antibody; VLA-BETA antibody; VLAB antibody; VLAbeta antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Integrins a-1/beta-1, a-2/beta-1, a-10/beta-1 and a-11/beta-1 are receptors for collagen. Integrins a-1/beta-1 and a-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins a-2/beta-1, a-3/beta-1, a-4/beta-1, a-5/beta-1, a-8/beta-1, a-10/beta-1, a-11/beta-1 and a-V/beta-1 are receptors for fibronectin. a-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin a-5/beta-1 is a receptor for fibrinogen. Integrin a-1/beta-1, a-2/beta-1, a-6/beta-1 and a-7/beta-1 are receptors for lamimin. Integrin a-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin a-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin a-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. a-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin a-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with a-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis Balzac F., Retta S.F., Albini A., Melchiorri A., Koteliansky V.E., Geuna M. J. Cell Biol. 127:557-565(1994) Chuang N.N., Huang C.C.Biochem. Soc. Trans. 35:1292-1294(2007) Pellinen T., Tuomi S., Arjonen A., Wolf M. J. Dev. Cell 15:371-385(2008)
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.790~794 (V-V-N-P-K) derived from Human Integrin b1 (CD29).
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:ITGB1-Antibody-11083304.html
