UBE2N Antibody, FITC conjugated
Product Sizes
50 ug
£186.00
CSB-PA025470LC01HU-50UG
100 ug
£334.00
CSB-PA025470LC01HU-100UG
About this Product
- SKU:
- CSB-PA025470LC01HU
- Additional Names:
- Bendless like ubiquitin conjugating enzyme antibody; Bendless-like ubiquitin-conjugating enzyme antibody; BLU antibody; EC 6.3.2.19 antibody; Epididymis secretory protein Li 71 antibody; HEL-S-71 antibody; Human epidermoid carcinoma mRNA for ubiquitin-conjugating enzyme E2 similar to Drosophila bendless gene product complete cds antibody; MGC131857 antibody; MGC8489 antibody; UBC 13 antibody; Ubc13 antibody; UbCH ben antibody; UbcH-ben antibody; UbcH13 antibody; UBCHBEN antibody; Ube 2N antibody; Ube2n antibody; UBE2N_HUMAN antibody; Ubiquitin carrier protein N antibody; Ubiquitin conjugating enzyme E2 N antibody; Ubiquitin conjugating enzyme E2N (homologous to yeast UBC13) antibody; Ubiquitin conjugating enzyme E2N (UBC13 homolog yeast) antibody; Ubiquitin conjugating enzyme E2N antibody; Ubiquitin protein ligase N antibody; Ubiquitin-conjugating enzyme E2 N antibody; Ubiquitin-protein ligase N antibody; Yeast UBC13 homolog antibody
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Clonality:
- Polyclonal
- Conjugate:
- FITC
- Extra Details:
- The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Ubiquitin-conjugating enzyme E2 N protein (20-138AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:UBE2N-Antibody-FITC-conjugated-12782013.html
