TICAM1 Antibody
Product Sizes
100 ul
£445.00
CSB-PA023532KA01HU-100UL
About this Product
- SKU:
- CSB-PA023532KA01HU
- Additional Names:
- IIAE6 antibody; MGC35334 antibody; MyD88 3 antibody; Proline rich vinculin and TIR domain containing protein B antibody; Proline-rich antibody; PRVTIRB antibody; Putative NF kappa B activating protein 502H antibody; Putative NF-kappa-B-activating protein 502H antibody; Putative NFkB activating protein antibody; TCAM1_HUMAN antibody; TICAM 1 antibody; TICAM-1 antibody; Ticam1 antibody; TIR domain containing adapter molecule 1 antibody; TIR domain containing adapter protein inducing IFN beta antibody; TIR domain containing adaptor inducing interferon beta antibody; TIR domain-containing adapter molecule 1 antibody; TIR domain-containing adapter protein inducing IFN-beta antibody; Toll interleukin 1 receptor domain containing adapter protein inducing interferon beta antibody; Toll like receptor adaptor molecule 1 antibody; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta antibody; TRIF antibody; TRIF protein antibody; vinculin and TIR domain-containing protein B antibody
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
- Clonality:
- Polyclonal
- Extra Details:
- Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-K KappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IK KappaB that normally maintains NF-K KappaB inactivity by sequestering it in the cytoplasm.TRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-K KappaB, IRF3 and trigger IFN-B Beta production. Studies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectively. TRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-K KappaB activation. In addition, TRIF can trigger signaling of that lead to the induction of apoptosis.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of Human TICAM1
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:TICAM1-Antibody-1035605.html
