SRPK2 Antibody, HRP conjugated
Product Sizes
50 ul
£186.00
CSB-PA022683LB01HU-50UL
100 ul
£334.00
CSB-PA022683LB01HU-100UL
About this Product
- SKU:
- CSB-PA022683LB01HU
- Additional Names:
- Human serine kinase SRPK2 mRNA, complete cds antibody; Serine kinase SRPK2 antibody; Serine/arginine rich protein specific kinase 2 antibody; Serine/arginine-rich protein-specific kinase 2 antibody; Serine/threonine protein kinase SRPK2 antibody; SFRS protein kinase 2 antibody; SFRSK2 antibody; SR protein specific kinase 2 antibody; SR-protein-specific kinase 2 antibody; SRPK2 antibody; SRPK2_HUMAN antibody; SRSF protein kinase 2 C-terminal antibody
- Application:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Clonality:
- Polyclonal
- Conjugate:
- HRP
- Extra Details:
- Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human SRSF protein kinase 2 protein (471-688AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:SRPK2-Antibody--HRP-conjugated-12925898.html
