SRSF1 Antibody
Product Sizes
50 ul
£186.00
CSB-PA021142ESR2HU-50UL
100 ul
£334.00
CSB-PA021142ESR2HU-100UL
About this Product
- SKU:
- CSB-PA021142ESR2HU
- Additional Names:
- Alternative splicing factor 1 antibody; Alternative-splicing factor 1 antibody; arginine/serine-rich 1 antibody; ASF 1 antibody; ASF antibody; ASF-1 antibody; ASF1 antibody; FLJ53078 antibody; MGC5228 antibody; P33 subunit antibody; Pre mRNA splicing factor SF2 P33 subunit antibody; pre-mRNA-splicing factor SF2 antibody; Serine/arginine-rich splicing factor 1 antibody; SF2 antibody; SF2P33 antibody; SFRS1 antibody; Splicing factor 2 alternate splicing factor antibody; Splicing factor 2 antibody; Splicing factor antibody; Splicing factor arginine/serine rich 1 antibody; SR Splicing factor 1 antibody; SRp30a antibody; srsf1 antibody; SRSF1_HUMAN antibody
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Serine/arginine-rich splicing factor 1 protein (1-248AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:SRSF1-Antibody-11081775.html
