PSMD10 Antibody, FITC conjugated
Product Sizes
50 ug
£186.00
CSB-PA018899LC01HU-50UG
100 ug
£334.00
CSB-PA018899LC01HU-100UG
About this Product
- SKU:
- CSB-PA018899LC01HU
- Additional Names:
- 26S proteasome non-ATPase regulatory subunit 10 antibody; 26S proteasome regulatory subunit p28 antibody; Ankyrin repeat protein antibody; dJ889N15.2 antibody; Gankyrin antibody; Hepatocellular carcinoma-associated protein p28 II antibody; p28 antibody; p28(GANK) antibody; Proteasome (prosome, macropain) 26S subunit, non ATPase, 10 antibody; Proteasome 26S S10 antibody; PSD10_HUMAN antibody; Psmd10 antibody
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Clonality:
- Polyclonal
- Conjugate:
- FITC
- Extra Details:
- Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human 26S proteasome non-ATPase regulatory subunit 10 protein (1-226AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:PSMD10-AntibodyFITC-conjugated-11082083.html
