POLD1 Antibody, FITC conjugated
Product Sizes
50 ug
£186.00
CSB-PA018303LC01HU-50UG
100 ug
£334.00
CSB-PA018303LC01HU-100UG
About this Product
- SKU:
- CSB-PA018303LC01HU
- Additional Names:
- Polymerase (DNA directed) delta 1 catalytic subunit antibody; CDC2 antibody; CDC2 homolog antibody; CRCS10 antibody; DNA directed DNA polymerase delta 1 antibody; DNA directed polymerase delta 1 antibody; DNA pol delta 1 antibody; DNA polymerase delta catalytic subunit antibody; DNA polymerase subunit delta p125 antibody; DPOD1_HUMAN antibody; MDPL antibody; POLD antibody; POLD 1 antibody; POLD1 antibody; Polymerase (DNA directed) delta 1 catalytic subunit 125kDa antibody; Polymerase (DNA) delta 1 catalytic subunit antibody; Polymerase DNA directed delta 1 catalytic subunit 125kD antibody; polymerase, DNA, delta antibody
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Clonality:
- Polyclonal
- Conjugate:
- FITC
- Extra Details:
- As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200, PubMed:24022480). Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human DNA polymerase delta catalytic subunit protein (1-123AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:POLD1-Antibody-FITC-conjugated-12781929.html
