NEK2 Antibody
Product Sizes
50 ul
£186.00
CSB-PA015699ESR1HU-50UL
100 ul
£334.00
CSB-PA015699ESR1HU-100UL
About this Product
- SKU:
- CSB-PA015699ESR1HU
- Additional Names:
- HSPK 21 antibody; HsPK21 antibody; NEK 2 antibody; NEK2 antibody; NEK2_HUMAN antibody; NEK2A antibody; Never in mitosis A-related kinase 2 antibody; NIMA (never in mitosis gene a) related kinase 2 antibody; NimA like protein kinase 1 antibody; NIMA related kinase 2 antibody; NimA related protein kinase 2 antibody; NimA-like protein kinase 1 antibody; NimA-related protein kinase 2 antibody; NLK 1 antibody; NLK1 antibody; Serine/threonine-protein kinase Nek2 antibody
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Serine/threonine-protein kinase Nek2 protein (1-135AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:NEK2-Antibody-1091940.html
