MCC Antibody, FITC conjugated

Product Sizes

50 ug

£186.00

CSB-PA013571LC01HU-50UG

100 ug

£334.00

CSB-PA013571LC01HU-100UG

About this Product

SKU:: CSB-PA013571LC01HU
Additional Names:: Colorectal mutant cancer protein antibody; CRCM_HUMAN antibody; DKFZp762O1615 antibody; FLJ38893 antibody; FLJ46755 antibody; MCC 1 antibody; MCC antibody; MCC1 antibody; Mutated in colorectal cancers antibody; Protein MCC antibody
Buffer:: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Clonality:: Polyclonal
Conjugate:: FITC
Extra Details:: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).
Host:: Rabbit
Immunogen:: Recombinant Human Colorectal mutant cancer protein (479-611AA)
Isotype:: IgG
Physical State:: Liquid
Purification:: Protein G Purified
Reactivities:: Human
Shipping Conditions:: Blue Ice
Storage Conditions:: -20[o]C/-70[o]C Avoid freeze/thaw cycles.
Supplier:: Cusabio
Type:: Antibody: Polyclonal Antibody

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