LRP6 Antibody
Product Sizes
50 ul
£186.00
CSB-PA013102ESR2HU-50UL
100 ul
£334.00
CSB-PA013102ESR2HU-100UL
About this Product
- SKU:
- CSB-PA013102ESR2HU
- Additional Names:
- ADCAD2 antibody; C030016K15Rik antibody; Cd antibody; FLJ90062 antibody; FLJ90421 antibody; LDL receptor related protein 6 antibody; Low density lipoprotein receptor related protein 6 antibody; Low-density lipoprotein receptor-related protein 6 antibody; LRP-6 antibody; LRP6 antibody; LRP6_HUMAN antibody; OTTHUMP00000238979 antibody; OTTHUMP00000238980 antibody; OTTHUMP00000238982 antibody; STHAG7 antibody
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Low-density lipoprotein receptor-related protein 6 protein (20-150AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:LRP6-Antibody-1091981.html
