KPNA6 Antibody
Product Sizes
50 ul
£186.00
CSB-PA012488ESR2HU-50UL
100 ul
£334.00
CSB-PA012488ESR2HU-100UL
About this Product
- SKU:
- CSB-PA012488ESR2HU
- Additional Names:
- FLJ11249 antibody; IMA7_HUMAN antibody; Importin alpha 7 subunit antibody; Importin alpha S2 antibody; Importin subunit alpha 7 antibody; Importin subunit alpha-7 antibody; IPOA 7 antibody; IPOA7 antibody; Karyopherin alpha 6 antibody; Karyopherin alpha 6 (importin alpha 7) antibody; Karyopherin subunit alpha 6 antibody; Karyopherin subunit alpha-6 antibody; KPNA 6 antibody; KPNA 7 antibody; Kpna6 antibody; KPNA7 antibody; MGC17918 antibody; OTTHUMP00000004532 antibody
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Importin subunit alpha-7 protein (277-536AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:KPNA6-Antibody-11909142.html
