HUS1 Antibody
Product Sizes
50 ug
£186.00
CSB-PA010909LA01HU-50UG
100 ug
£334.00
CSB-PA010909LA01HU-100UG
About this Product
- SKU:
- CSB-PA010909LA01HU
- Additional Names:
- Checkpoint protein HUS1 antibody; hHUS1 antibody; HUS1 (S. pombe) checkpoint homolog antibody; Hus1 antibody; HUS1 checkpoint homolog (S. pombe) antibody; HUS1 Checkpoint Protein antibody; HUS1 protein antibody; HUS1+ - like protein antibody; HUS1_HUMAN antibody; Hydroxyurea-sensitive 1, S. pombe, homolog of antibody
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Clonality:
- Polyclonal
- Extra Details:
- Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Checkpoint protein HUS1 protein (2-280AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:HUS1-Antibody-1027995.html
