H2AFX (Ab-142) Antibody
Product Sizes
50 ul
£186.00
CSB-PA010097PA142NPHHU-50UL
100 ul
£334.00
CSB-PA010097PA142NPHHU-100UL
About this Product
- SKU:
- CSB-PA010097PA142NPHHU
- Additional Names:
- Histone H2AX (H2a/x) (Histone H2A.X), H2AFX, H2AX
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Clonality:
- Polyclonal
- Extra Details:
- Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from Human Histone H2AX protein (130-142aa)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:H2AFX--Ab-142--Antibody-12930661.html
