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Antibodies

GDF5 Antibody

Product Sizes
50 ul
£186.00
CSB-PA009349ESR1HU-50UL
100 ul
£334.00
CSB-PA009349ESR1HU-100UL
About this Product
SKU:
CSB-PA009349ESR1HU
Additional Names:
BMP14 antibody; Cartilage derived morphogenetic protein 1 antibody; Cartilage-derived morphogenetic protein 1 antibody; CDMP-1 antibody; CDMP1 antibody; GDF-5 antibody; Gdf5 antibody; GDF5_HUMAN antibody; Growth differentiation factor 5 antibody; Growth/differentiation factor 5 antibody; LAP4 antibody; OS5 antibody; Radotermin antibody; SYNS2 antibody
Application:
ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Buffer:
PBS
Clonality:
Polyclonal
Extra Details:
Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Host:
Rabbit
Immunogen:
Recombinant Human Growth/differentiation factor 5 protein (202-501AA)
Isotype:
IgG
Physical State:
Liquid
Purification:
Affinity Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles.
Supplier:
Cusabio
Type:
Antibody: Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA009349ESR1HU at dilution of 1:100
Immunofluorescence staining of A549 cells with CSB-PA009349ESR1HU at 1:44, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of CSB-PA009349ESR1HU diluted at 1:132 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA009349ESR1HU diluted at 1:132 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Western Blot Positive WB detected in: NIH/3T3 whole cell lysate All lanes: GDF5 antibody at 2.64ug/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 56 kDa Observed band size: 56 kDa