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Antibodies

CDK3 Antibody

Product Sizes
50 ug
£186.00
CSB-PA005064LA01HU-50UG
100 ug
£334.00
CSB-PA005064LA01HU-100UG
About this Product
SKU:
CSB-PA005064LA01HU
Additional Names:
Cdk 3 antibody; Cdk3 antibody; CDK3_HUMAN antibody; CDKN3 antibody; Cell division kinase 3 antibody; Cell division protein kinase 3 antibody; Cyclin dependent kinase 3 antibody; Cyclin-dependent kinase 3 antibody; OTTHUMP00000206828 antibody; p36 antibody
Application:
ELISA, Immunohistochemistry
Buffer:
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Clonality:
Polyclonal
Extra Details:
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
Host:
Rabbit
Immunogen:
Recombinant Human Cyclin-dependent kinase 3 protein (220-297AA)
Isotype:
IgG
Physical State:
Liquid
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles.
Supplier:
Cusabio
Type:
Antibody: Polyclonal Antibody
IHC image of CSB-PA005064LA01HU diluted at 1:600 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.