TP53 Monoclonal Antibody
Product Sizes
100 ul
£429.00
CSB-MA989534-100UL
About this Product
- SKU:
- CSB-MA989534
- Additional Names:
- P53; LFS1; TRP53; TP53
- Application:
- ELISA, Western Blot
- Buffer:
- Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
- Clonality:
- Monoclonal
- Extra Details:
- Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
- Host:
- Mouse
- Immunogen:
- Purified recombinant human p53 protein fragments expressed in E.coli.
- Isotype:
- IgG2b
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:TP53-Monoclonal-Antibody-11080481.html
