CD163 Monoclonal Antibody
Product Sizes
50 ul
£186.00
CSB-MA942955-50UL
100 ul
£334.00
CSB-MA942955-100UL
About this Product
- SKU:
- CSB-MA942955
- Additional Names:
- Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)], CD163, M130
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Monoclonal
- Extra Details:
- Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
- Host:
- Mouse
- Immunogen:
- Synthesized peptide derived from human CD163
- Isotype:
- IgG1, kappa
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:CD163-Monoclonal-Antibody-12934694.html
