GAPDH Monoclonal Antibody
Product Sizes
50 ul
£193.00
CSB-MA000071M2M-50UL
100 ul
£224.00
CSB-MA000071M2M-100UL
About this Product
- SKU:
- CSB-MA000071M2M
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- translate.label.attr.clone:
- 10H4D6
- Clonality:
- Monoclonal
- Extra Details:
- Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of 37kDa that is consisdered as a cellular enzyme involved in glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. At the molecular level, sequential steps lead to nuclear translocation of GAPDH during cell death as follows: first, a catalytic cysteine in GAPDH (C150 in rat GAPDH) is S-nitrosylated by nitric oxide (NO) that is generated from inducible nitric oxide synthase (iNOS) and/or neuronal NOS (nNOS); second, the modified GAPDH becomes capable of binding with Siah1, an E3 ubiquitin ligase, and stabilizes it; third, the GAPDH-Siah protein complex translocates to the nucleus, dependent on Siah1's nuclear localization signal, and degrades Siah1's substrates in the nucleus, which results in cytotoxicity. A recent report suggests that GAPDH may be genetically associated with late-onset of Alzheimer's disease.-deprenyl, which has originally been used as a monoamine oxidase inhibitor for Parkinson's disease, binds to GAPDH and displays neuroprotective actions.
- Host:
- Mouse
- Immunogen:
- Recombinant Human GAPDH protein (2-335AA)
- Isotype:
- IgG1
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Human, Mouse, Rabbit, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:GAPDH-Monoclonal-Antibody-12928580.html
