Anti Collagen 4 (Alpha 5) monoclonal antibody (Clone H52)
Product Sizes
500 ul
SGE-C452-500UL
About this Product
- SKU:
- SGE-C452
- Application:
- Immunofluorescence, Western Blot
- translate.label.attr.clone:
- Clone h52
- Clonality:
- Monoclonal
- Extra Details:
- Check out our Human Collagen IVA Alpha Rat Monoclonal Antibodies Dashboard for more information about this product and additional epitope-defined monoclonal antibodies useful for research on hereditary diseases related to collagen IV, including our popular Anti-Collagen 4 Cocktail mAb (Clones H53, B51, H25) (SGE-CFT45325). Alport syndrome is an inherited disease characterized by the pathological absence or reduction of the collagen A Alpha5(IV) chain in glomerular basement membrane (GBM), tubular basement membrane (TBM) and Bowman's capsular basement membrane. Anti Collagen 4 (Alpha 5) mAb (Clone H52) (cat no. SGE-C452) is an unlabeled rat monoclonal antibody specific for the A Alpha5 chain of collagen IV. It is useful in Western blot and indirect immunofluorescence experiments. Product specifications References
- Kagawa M et al. Epitope-defined monoclonal antibodies against type-IV collagen for diagnosis of Alport syndrome. Nephrol. Dial. Transplant. 12: 1238-1241 (1997) (PMID: 9198058) Borza DB et al. The NCI domain of collagen IV encodes a novel network composed of the A Alpha1, A Alpha2, A Alpha5, and A Alpha6 chains in smooth muscle basement membranes. J. Biol. Chem. 276: 28532-28540 (2001) (PMID: 11375996) Sado et al. Establishment by the rat lymph node method of epitope-defined monoclonal antibodies recognizing the six different A Alpha chains of human type IV collagen. Histochem. Cell Biol. 104: 267-275 (1995) (PMID: 8548560) Yoshioka K et al. Type IV collagen A Alpha5 chain: Normal distribution and abnormalities in X-linked Alport syndrome revealed by monoclonal antibody. Am. J. Pathol. 144: 986-996 (1994) (PMID: 8178947) Ninomiya Y et al. Differential expression of two basement membrane collagen genes, COL4A6 and COL4A5, demonstrated by immunofluorescence staining using peptide-specific monoclonal antibodies. J. Cell Biol. 130: 1219-1229 (1995) (PMID: 7657706) Naito I et al. Relationship between COL4A5 gene mutation and distribution of type IV collagen in male X-linked Alport syndrome. Kidney Int. 50: 304-311 (1996) (PMID: 8807602)
- Bu L et al. Somatic Mosaicism in a Male Patient With X-linked Alport Syndrome. Kidney Int Rep. 14(4): 1031-1035 (2019) (PMID: 31312776) Samar M et al. Negative Staining for COL4A5 Correlates With Worse Prognosis and More Severe Ultrastructural Alterations in Males With Alport Syndrome. Kidney Int Rep. 2(1): 44-52 (2017) (PMID: 29142939) Malone AF et al. Functional assessment of a novel COL4A5 splice region variant and immunostaining of plucked hair follicles as an alternative method of diagnosis in X-linked Alport syndrome. Pediatr Nephrol. 32(6): 997-1003 (2017) (PMID: 28013382) Nozu K et al. X-linked Alport syndrome caused by splicing mutations in COL4A5. Am Soc Nephrol. 9(11): 1958-64 (2014) (PMID: 25183659) Matsubara S et al. Pregnancy complicated with Alport syndrome: a good obstetric outcome and failure to diagnose an infant born to a mother with Alport syndrome by umbilical cord immunofluorescence staining. Obstet Gynaecol Res. 35(6): 1109-14 (2009) (PMID: 20144175) Patey-Mariaud de Serre N et al. Collagen alpha5 and alpha2(IV) chain coexpression: analysis of skin biopsies of Alport patients. Kidney Int. 72(4): 512-6 (2007) (PMID: 17554254) Kharrat M et al. Autosomal dominant Alport's syndrome: study of a large Tunisian family. Kidney Dis Transpl. 17(3): 320-5 (2006) (PMID: 16970251)
- Host:
- Rat
- Immunogen:
- Collagen 4 (Alpha 5)
- Reactivities:
- Bovine, Human, Rabbit, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Cosmo Bio Ltd
- Type:
- Antibody: Monoclonal Antibody