Anti AGEs monoclonal antibody (Clone 6D12)
Product Sizes
10 ug
KAL-KH001-10UG
About this Product
- SKU:
- KAL-KH001
- Application:
- ELISA, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- Clone 6d12
- Clonality:
- Monoclonal
- Extra Details:
- Reaction of protein amino groups with glucose leads, through the early products such as a Schiff base and Amadori rearrangement products, to the formation of advanced glycation end products (AGEs). Recent immunological studies using anti-AGEs antibody (6D12) demonstrated the presence of AGEs-modified proteins in several human tissues: human lens (nondiabetic and noncataractous), ( patients with diabetic nephropathy and chronic renal failure, renal proximal tubules in diabetic retina, diabetic neuropathy, atherosclerotic lesions of arterial walls, peripheral nerves of 2-microglobulin forming amyloid fibrils in patients with hemodialysis-related amyloidosis, the peritoneum of CAPD patients, senile plaques of patients with Alzheimer's disease, ( ) skin elastin in actinic elastosis, andceriod/lipofuscin deposits. These results suggest a potential role of AGEs-modification in normal aging as well as age-enhanced disease processes. This antibody named as 6D12 has been used to demonstrate AGEs-modified proteins in these human tissues, indicating potential usefulness of this antibody for histochemical identification and biochemical quantification of AGEs-modified proteins., KAL
- Host:
- Mouse
- Immunogen:
- AGEs
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Cosmo Bio Ltd
- Type:
- Antibody: Monoclonal Antibody