Anti Interleukin-32 (IL32) polyclonal antibody (Rabbit, Antiserum)
Product Sizes
100 ul
CAC-SU-IZ-P02-100UL
About this Product
- SKU:
- CAC-SU-IZ-P02
- Application:
- Flow Cytometry, Western Blot
- Clonality:
- Polyclonal
- Extra Details:
- Human recombinant IL-32 does not exhibit similarities with known cytokine families, yet several properties are typical of a pro-inflammatory cytokine. It was discovered accidentally while studying the genes induced by IL-18 and was found to stimulate the production of various chemokines, pro-inflammatory cytokines including IL-1B Beta, IL-6, IL-8, TNF-A Alpha and macrophage inflammatory protein-2 (MIP-2). Inflammation or infection with various pathogens including Mycobacterium tuberculosis, Epstein-Barr virus (EBV), human immunodeficiency virus (HIV) and influenza A virus have been reported to induce the expression of IL-32. The IL-32 gene is located on human chromosome 16 p13.3, which is organized into eight exons with six splice variants of the gene; these variants have been described as IL-32A Alpha, IL-32B Beta, IL-32G Gamma, IL-32D Delta, IL-32E Epsilon and IL-32Z Zeta, of which, IL-32A Alpha is the most abundant transcript. Anti-tumor activity of NK cells is provoked by IL-12 and IL-18, both of which induce IL-32 production that stimulates TNF-A Alpha synthesis enhancing NK apoptotic activity. IL-32 was found in cytosol as well as in the nucleus. Park et al. reported that IL-32 enhances the anti-tumor activity specifically for NK-92 cells upon introduction of the death receptor and the activation of caspase-3 pathway in cancer cells. IL-32 has been reported to play a key role in the pathogenesis of various disorders, including infectious autoimmune and inflammatory diseases. Anti-IL-32 polyclonal antibody obtained from rabbit immunization with purified E. coli-derived recombinant human IL-32. This antibody can be used for the detection of IL-32 by immunoblotting and flow cytometry. References: Goda, C et al., Int. Immunol. 18:233-240, 2006, CAC
- Host:
- Rabbit
- Immunogen:
- Interleukin-32 (IL32)
- Reactivities:
- Human
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Cosmo Bio Ltd
- Type:
- Antibody: Polyclonal Antibody
