Anti DNA Repair Protein Complementing XP-G Cells (XPG/ERCC5) monoclonal antibody (Clone G-26)
Product Sizes
100 ul
£682.00
CAC-KUP-TM-M03-100UL
About this Product
- SKU:
- CAC-KUP-TM-M03
- Application:
- Western Blot
- translate.label.attr.clone:
- Clone g-26
- Clonality:
- Monoclonal
- Extra Details:
- Nucleotide excision repair (NER) is a major repair system for removing a variety of DNA lesions including UV-induced cyclobutane pyrimidine dimers and (6-4) photoproducts as well as chemically-induced bulky base adducts. Defects in the NER system give rise to xeroderma pigmentosum (XP), an autosomal recessive disease characterized by a predisposition to skin cancer and in some cases neurological abnormalities. The early process of human NER, from damage recognition to dual incision (removal of damage-containing oligonucleotides), is accomplished by six core NER factors, XPC-RAD23B, TFIIH, XPA, RPA, XPF-ERCC1 and XPG. XPG is a structure-specific endonuclease with an opposite polarity to ERCC1-XPF and makes a nick on the DNA strand which makes the transition from single-stranded to duplex DNA in the 5' to 3' direction. In the NER process, XPG is responsible for 3'-incision at a dual incision step. References: Oyama M, Wakasugi M, Hama T, et al., Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen. Biochem. Biophys. Res. Commun. 321, 183-191 (2004)., CAC
- Host:
- Mouse
- Immunogen:
- DNA Repair Protein Complementing XP-G Cells (XPG/ERCC5)
- Reactivities:
- Human
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Cosmo Bio Ltd
- Type:
- Antibody: Monoclonal Antibody
