Anti DNA Repair Endonuclease XPF (XPF/ERCC4) monoclonal antibody (Clone 19-16)
Product Sizes
100 ul
£682.00
CAC-KUP-TM-M02-100UL
About this Product
- SKU:
- CAC-KUP-TM-M02
- Application:
- Immunofluorescence, Western Blot
- translate.label.attr.clone:
- Clone 19-16
- Clonality:
- Monoclonal
- Extra Details:
- Nucleotide excision repair (NER) is a major repair system for removing a variety of DNA lesions including UV-induced cyclobutane pyrimidine dimers and (6-4) photoproducts as well as chemically-induced bulky base adducts. Defects in the NER system give rise to xeroderma pigmentosum (XP), an autosomal recessive disease characterized by a predisposition to skin cancer and in some cases neurological abnormalities. The early process of human NER, from damage recognition to dual incision (removal of damage-containing oligonucleotides), is accomplished by six core NER factors, XPC-RAD23B, TFIIH, XPA, RPA, XPF-ERCC1 and XPG. XPF harbors a nuclease domain and forms a stable complex with ERCC1. The ERCC1-XPF complex has a unique ability to make a nick on the DNA strand which makes the transition from duplex to single-stranded DNA in the 5' to 3' direction. In the NER process, ERCC1-XPF is responsible for 5'-incision at a dual incision step., CAC
- Host:
- Mouse
- Immunogen:
- DNA Repair Endonuclease XPF (XPF/ERCC4)
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Cosmo Bio Ltd
- Type:
- Antibody: Monoclonal Antibody
