Anti Microtubule-Associated Proteins 1A/1B Light Chain 3A (MAP1LC3A/LC3) monoclonal antibody (Clone LC3-1703)
Product Sizes
50 ug
£714.00
CAC-CTB-LC3-2-IC-50UG
About this Product
- SKU:
- CAC-CTB-LC3-2-IC
- Application:
- Immunocytochemistry, Immunoelectron Microscopy, Immunofluorescence
- translate.label.attr.clone:
- Clone lc3-1703
- Clonality:
- Monoclonal
- Extra Details:
- LC3 is a mammalian autophagosome marker. It is immediately cleaved to form LC3-I by Atg4, and when autophagy is induced, phosphatidylethanolamine is covalently linked to LC3-I C-terminal glycine to form LC3-II. LC3-II is membrane-bound and thought to be present in autophagosomal membranes. Since autophagosomes are degraded by fusion with lysosomes, LC3-II itself is also degraded by autophagy. Therefore, it is generally accepted that the amount of LC3-II correlates well with the amount of autophagosomes. This antibody shows good results in ICC and Immunoelectron microscopy experiments. Source: Professor Noboru Mizushima, Department of Cell Physiology, Tokyo Medical and Dental University References: 1) Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y. and Yoshimori, T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J. 19, 5720-5728. (2000) 2) Mizushima, N., Yoshimori, T. How to interpret LC3 immunoblotting Autophagy 3:542-545 (2007) 3) Mizushima, N., Yoshimori, T. and Levine, B. Methods in mammalian autophagy research. Cell 140; 313-326 (2010), CAC
- Host:
- Mouse
- Immunogen:
- Microtubule-Associated Proteins 1A/1B Light Chain 3A (MAP1LC3A/LC3)
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Cosmo Bio Ltd
- Type:
- Antibody: Monoclonal Antibody
