Anti Importin-4 (IPO4) monoclonal antibody (Clone 3C2)
Product Sizes
100 ug
£890.00
CAC-CEC-023-100UG
About this Product
- SKU:
- CAC-CEC-023
- Application:
- Immunocytochemistry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- Clone 3c2
- Clonality:
- Monoclonal
- Extra Details:
- Background Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. [from: The UniProt Consortium, UniProt: a worldwide hub of protein knowledge, Nucleic Acids Research, Volume 47, Issue D1, 08 January 2019, Pages D506-D515, https://doi.org/10.1093/nar/gky1049] Application Western blotting : Recommended dilutions 1/1000 to 1/5000 Immunocytochemistry : Recommended dilutions 1/100 to 1/500 References 1) Miyauchi et al. (2005) J. Biol. Chem. 280:40901-40908. 2) Wang et al. (2010) PNAS. 107:16131-16136., CAC
- Host:
- Rat
- Immunogen:
- Importin-4 (IPO4)
- Reactivities:
- Hamster, Human, Mouse, Non-human Primate, Rat
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- Cosmo Bio Ltd
- Type:
- Antibody: Monoclonal Antibody
