HPAF-II Cells-Pancreas cancer cell lines
Product Sizes
1 each
305088-1EACH
About this Product
- SKU:
- 305088
- Additional Names:
- HPAF II, HPAFII, HPAF-2, HPAF2, HPAF/CD18, CD18/HPAF, HPAF-II/CD18, CD-18, CD18, CD 18
- CE/IVD:
- Our cells are provided for in vitro laboratory research purposes exclusively and are not intended fo
- Extra Details:
- HPAF-II is a human pancreatic adenocarcinoma cell line derived from an adult patient. This cell line is commonly used in cancer research due to its relevance in studying pancreatic cancer, a highly aggressive and lethal malignancy. HPAF-II cells exhibit epithelial morphology and are known for their ability to form tumors when xenografted into immunocompromised mice, making them a valuable model for in vivo studies of tumor growth, metastasis, and response to therapeutic interventions. Researchers often employ HPAF-II cells to investigate the molecular mechanisms underlying pancreatic cancer progression, including genetic and epigenetic alterations, signal transduction pathways, and interactions with the tumor microenvironment. HPAF-II cells are characterized by specific genetic mutations and alterations that are frequently observed in pancreatic adenocarcinomas. These include mutations in the KRAS gene, which plays a critical role in cell signaling and proliferation, and alterations in tumor suppressor genes such as TP53 and CDKN2A. The cell line also exhibits high levels of mucin production, a feature that contributes to the aggressive nature of pancreatic tumors. Studies utilizing HPAF-II cells have provided significant insights into the biology of pancreatic cancer and have facilitated the development of potential therapeutic strategies aimed at targeting key molecular pathways involved in the disease.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Cytion
- Type:
- Cells: Cell Lines
- Manufacturer's Data Sheet:790ee87447b94756aabef96146b648ea
