U-251 MG Cells- Brain cancer cell lines
Product Sizes
1 each
300385-1EACH
About this Product
- SKU:
- 300385
- Additional Names:
- U-251MG, U-251-MG, U-251_MG, U251-MG, U251MG, U-251, U251, U251n, U251N, 251 MG, 251MG
- CE/IVD:
- Our cells are provided for in vitro laboratory research purposes exclusively and are not intended fo
- Extra Details:
- The U-251 MG cell line is a well-characterized human glioblastoma multiforme (GBM) cell line that is extensively used in neuro-oncology research. Derived originally from a 75-year-old Caucasian female, this cell line has been instrumental in the study of brain tumors, particularly in understanding the molecular and cellular mechanisms underlying malignant gliomas. The U-251 MG cells exhibit astrocytic properties, which are characteristic of their origin from astrocytes, the predominant cell type involved in GBM. Genetically, U-251 MG cells harbor mutations and alterations typical of high-grade astrocytomas, including mutations in the TP53 gene and loss of heterozygosity in chromosome 10, which encompasses the PTEN gene. These genetic traits contribute to the cell line's utility in studying tumor suppressor gene functions and the cellular pathways involved in tumor progression and resistance. The cells are also known for their robust in vitro growth rates and ability to form tumors when xenografted into immunocompromised mice, making them a valuable model for in vivo studies of tumor growth, invasion, and therapy response. Furthermore, U-251 MG has been employed in a multitude of studies focusing on therapeutic approaches, including chemotherapy resistance, radiation therapy outcomes, and the evaluation of novel anticancer compounds. Its extensive use in translational research highlights its relevance in bridging basic neuroscientific discoveries with clinical applications, particularly in the development of targeted therapies for glioblastoma.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Cytion
- Type:
- Cells: Cell Lines
- Manufacturer's Data Sheet:3015107dd3404582af806d6b8cedccdc
