CD32b FITC
Product Sizes
50 tests
£343.00
4100012-50TESTS
About this Product
- SKU:
- 4100012
- Application:
- Flow Cytometry
- translate.label.attr.clone:
- 4F5
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- The clone 4F5, a mouse monoclonal antibody recognizes anti- FcG GammaRIIb, a cell surface protein also known as CD32b. FcG GammaRII has two major isoforms named FcG GammaRIIa and FcG GammaRIIb with high degree of homology. The clone 4F5 selectively reacts with FcG GammaRIIb but not with FcG GammaRIIa. The CD32b antigen is widely expressed on the cell surface of circulating B lymphocytes, monocytes, neutrophils, myeloid dendritic cells (DCs), platelets and at very low levels on plasmacytoid DCs. FcG GammaRs (FcG GammaRI/CD64, FcG GammaRII/CD32, FcG GammaRIII/CD16, and FcG GammaRIV/CD16-2) play important roles in inflammatory cell activation, clearance, presentation of Ag, and maintenance of IgG homeostasis. Published reports claimed that 4F5 partially blocks the ligand-binding of FcRIIb and mediates an inhibitory signal by co-cross-linking FcRIIb with activating FcRs. Clone 4F5 supports study of the expression, regulation, and function of FcG GammaRIIb and may be useful in the area of therapeutic applications where the modulation of FcG GammaRIIb is required.
- Host:
- Mouse
- Purity:
- >95%
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Caprico Biotechnologies
- Type:
- Antibody: Monoclonal Antibody
