CD154 iFluor 488
Product Sizes
25 tests
£236.00
1068114-25TESTS
About this Product
- SKU:
- 1068114
- Application:
- Flow Cytometry
- translate.label.attr.clone:
- 5C8
- Clonality:
- Monoclonal
- Conjugate:
- iFluor™ 488
- Extra Details:
- The clone 5C8, a mouse monoclonal antibody, specifically recognizes a ~30-33 kDa activation-induced human CD4+ T cells surface molecule known as CD154 or CD40 ligand (CD40L). The CD40 interacts with CD154 through T cell-B cell activating molecule, gp39, TNF cytokine related activation protein. CD154 is primarily expressed on the surface of activated CD4+ T cells but can also be expressed by platelets, mast cells, macrophages, basophils, NK cells, B cells, CD8+ T cells as well as non-hematopoietic cells including smooth muscle cells, endothelial cells, and epithelial cells. CD154 plays important roles in the pathogenesis of certain blood cancer such as the CD4+ T cells of patients with CLL fail to express surface CD154 antigen even after CD3 ligation, and proximal and distal activation events are required for the neonatal CD4+ T cells for the CD154 gene transcription to establish the normal immune system.
- Host:
- Mouse
- Purity:
- >95%
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Caprico Biotechnologies
- Type:
- Antibody: Monoclonal Antibody
