Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Proteins and Peptides

Human Interleukin 10 (IL10), Active Protein

Product Sizes
50 ug
£1032.00
RPU54838-50UG
100 ug
£1260.00
RPU54838-100UG
1 mg
£5241.00
RPU54838-1MG
About this Product
SKU:
RPU54838
Additional Names:
CSIF|Cytokine Synthesis Inhibitory Factor|IL10A|TGIF
Application:
Detection/Quantitation, Tissue Culture
Buffer:
Freeze-dried powder|PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
CE/IVD:
RUO
Extra Details:
Human Interleukin 10 (IL10), Active Protein is a purified Eukaryotic Protein.
Formulation:
Freeze-dried powder
Immunogen:
Interleukin 10 (IL10)
Molecular Weight:
18kDa
Physical State:
freeze-dried
Purity:
>97%
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C Avoid freeze/thaw cycles.
Supplier:
Biomatik
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Catalog Protein.JPG
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 was initially reported to suppress cytokine secretion, antigen presentation and CD4 T cell activation. Further investigation has shown that IL-10 predominantly inhibits lipopolysaccharide (LPS) mediated induction of the pro-inflammatory cytokines TNFA Alpha, IL-1B Beta, IL-12, and IFNG Gamma made by cells such as macrophages and Th1 T cells. Therefore, THP1 cells were cultured in 24 well plates at a concentration of 106 cells/ml and activated by LPS (1ug/mL) in the absence or presence of IL-10 (5ng/mL, 10ng/mL) for 24h and production of IL-1B Beta was determined in the supernatants by cytokine specific ELISA. Activation of THP1 cells with LPS (1ug/mL) resulted in high levels of production of IL-1B Beta and strong inhibitory effects of IL-10 (5ng/mL, 10ng/mL) were observed on the production of IL-1B Beta as shown in Table 1.
Figure 2. SDS-PAGE