VEGF-A (pig) ELISA kit
Product Sizes
96 wells
£761.00
A05426-96WELLS
About this Product
- SKU:
- A05426
- Additional Names:
- ELISA|EIA|angionesis|chemotactism|VEGF|vascular endothelial growth factor|vascular permeability factor|VPF|placental growth factor|PLGF| VEGF-B| VEGF-C|VEGF-D|Fos-induced growth factor|FIGF|cystine knot
- Extra Details:
- Enzyme ImmunoAssay (EIA) is a technique to detect and quantify antigens (proteins; hormones…) or antibodies in samples. It relies on the ability of an antibody to bind a specific antigen. Either the antibody or the antigen is labelled with an enzyme whose substrate is a chromogen or a fluorogen converted in a measurable product (color or fluorescence).|Enzyme-linked Immunosorbent Assay (ELISA) is a type of EIA using a solid phase (ex: microtiter plate) coated with an antigen immobilizing the molecule to detect. Over the time; scientists have extended the term ELISA to EIAs using an antibody coating the solid phase. That explains why our EIA kits using coated antibodies are also called ELISA kits.|Vascular endothelial growth factor (VEGF-A or VEGF)(1); also known as vascular permeability factor (VPF)(2); has been discovered in 1983. It is a member of the VEGF family that includes in mammals placental growth factor (PLGF); VEGF-B; VEGF-C; and VEGF-D (also known as c-Fos-induced growth factor; FIGF)(1).|VEGF-A is a glycoprotein having several isoforms of 121 to 206 amino acids(1) with a molecular weight from 33 kDa to 57kDa. It is a homodimer stabilised by hydrophobic interactions and by a disulphide bound(3). The monomer structure contains a central antiparallel four-stranded β sheet with a cystine knot at the end (4).|VEGF-A is produced by many cells like fetal tissu; hematopoietic stem cells; epidermal keratinocytes; podocytes of the renal glomerulus; cardiac myocytes; prostatic epithelium; and certain epithelial cells of the adrenal cortex and lung(5). |The main function of the VEGF-A is the angionesis (formation of new capillaries from pre-existing vessels) during the embryogenesis(1) or during re-building of the blood vessel after an injury. It has also some secondary functions in the chemotacxis of macrophages/ granulocytes and in vasodilation (indirectly by NO release).|Due to its main function; overexpression of VEGF-A causes various diseases including cancer.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- +4[o]C
- Supplier:
- Bertin Technologies
- Type:
- Assay Kits: ELISAs
