Anthrax Edema Factor Assay kit
Product Sizes
96 wells
£ POA
A05230-96WELLS
About this Product
- SKU:
- A05230
- Additional Names:
- ELISA|Bacillus|Anthracis|Anthrax|edema|factor|Protective|Antigen
- Extra Details:
- Anthrax is an infectious disease due to Bacillus anthracis; a gram-positive; spore-forming bacterium. Among bioterrorist agents; anthrax is considered as one of the most potent and dangerous bio-agent and has been classifi ed in the A list of the Centers of Disease Control. The pathogenic power of this bacteria is due to an exotoxin; which is secreted into the host’s system when three nontoxic proteins link together to form a toxin complex. The three parts of the pathogen complex are protective antigen (PA); lethal factor (LF) and edema factor (EF).At molecular level; the PA binds to cell receptors where it is cleaved into PA20 and PA63. PA63 can competitively bind EF or LF or both. The PA-LF complex forms the lethal toxin (LTx) and the PA-EF complex forms the edema toxin (ETx). Once ETx is endocytosed; EF is released in cytosole. EF is a calmoduline and Ca2+ dependent adenylyl cyclase which catalyses the conversion of cytosolic adenosine triphosphate into cyclic adenosine monophosphate (cAMP) leading to edema.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Bertin Technologies
- Type:
- Assay Kits: ELISAs
