Haptoglobin, Phenotype 2-1
Product Sizes
1 mg
£220.00
16-16-080116-2-1-1MG
5 mg
£649.00
16-16-080116-2-1-5MG
About this Product
- SKU:
- 16-16-080116-2-1
- Additional Names:
- ELISA, Protein Chemistry, Inflammation, Sickle Cell Anemia, Glycosylation, Stroke, Central Nervous System Injury, Diabetes, Cardiovascular Disease, In Vitro Diagnostic, Iron Metabolism, Cancer|Zonulin, HPT, HP, BP, HP2ALPHA2, HPA1S
- Application:
- ELISA
- Buffer:
- Salt-free lyophilized solid.
- CAS Number:
- 9087-69-8
- CE/IVD:
- RUO
- Extra Details:
- Haptoglobin 2-1 (Hp2-1) is a heterozygous phenotype of the haptoglobin protein, formed by the combination of Hp1 and Hp2 alleles. This plasma glycoprotein serves a critical function by binding free hemoglobin released during red blood cell breakdown, preventing oxidative damage and iron loss while facilitating its removal via the reticuloendothelial system. Hp2-1 represents an intermediate phenotype between Hp1-1 and Hp2-2 in terms of functionality and disease association. While Hp1-1 offers superior antioxidant capacity and hemoglobin binding efficiency, Hp2-1 provides moderate protection. This has significant clinical implications, particularly in diabetes, where Hp2-1 carriers have lower cardiovascular disease risk than Hp2-2 individuals but higher risk than Hp1-1 carriers. Diagnostically, haptoglobin phenotyping via tests like the Haptoglobin Typing ELISA helps identify diabetic patients who might benefit from specific interventions, such as vitamin E supplementation. Haptoglobin testing also aids in diagnosing and monitoring hemolytic anemia and other conditions involving accelerated red blood cell destruction.
- Formulation:
- Salt-free lyophilized solid.
- Molecular Weight:
- 200,000 Da
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Supplier:
- Athens Bioscience, Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
