C4b-Binding Protein
Product Sizes
0.1 mg
16-16-030402-0.1MG
1 mg
16-16-030402-1MG
About this Product
- SKU:
- 16-16-030402
- Additional Names:
- C4bBP, C4BP|Complement System, Inflammation, Antimicrobial, Autoimmune, Cancer, Alzheimer's
- Buffer:
- Lyophilized from 10 mM Tris pH 7.4, 100 mM NaCl, 0.05% NaN3 Free of Protein S
- CE/IVD:
- RUO
- Extra Details:
- C4b-binding protein (C4BP) is a glycoprotein synthesized in the liver, circulating at ~200 ug/mL in plasma, and functioning as a key inhibitor of the classical and lectin complement pathways. Its octopus-like structure comprises seven A Alpha-chains (70 kDa each) and one B Beta-chain (40 kDa) in the predominant isoform (A Alpha7B Beta1), though B Beta-deficient isoforms (A Alpha7B Beta0, A Alpha6B Beta1) exist, with A Alpha7B Beta0 upregulated during acute inflammation. The A Alpha-chain complement control protein (CCP) domains 1-3 mediate binding to C4b and heparin, while the B Beta-chain interacts with protein S, forming a calcium-dependent complex critical for anticoagulant activity. C4BP accelerates decay of C3/C5 convertases and acts as a cofactor for factor I in proteolytic cleavage of C4b/C3b, preventing excessive complement activation. Clinically, C4BP is implicated in neurodegenerative, autoimmune, and oncological disorders. In Alzheimer's disease, C4BP binds amyloid-B Beta plaques and apoptotic neurons, mitigating neuroinflammation by limiting complement-mediated damage. Elevated plasma C4BP correlates with psoriasis severity, where it modulates alternative pathway activation in skin lesions. Therapeutic administration of C4BP in murine rheumatoid arthritis models reduced joint inflammation by inhibiting classical and alternative pathways. Paradoxically, reduced C4BPA expression in breast and lung cancers associates with poor prognosis, suggesting tumor-suppressive roles via immune regulation.
- Formulation:
- Lyophilized from 10 mM Tris pH 7.4, 100 mM NaCl, 0.05% NaN3 Free of Protein S
- Molecular Weight:
- ~ 570,000 Da (whole molecule) ~ 70,000-75,000 Da (alpha chains) ~ 40,000-45,000 Da (beta chain)
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
