Complement C3c
Product Sizes
1 mg
16-16-030303-1MG
10 mg
16-16-030303-10MG
About this Product
- SKU:
- 16-16-030303
- Additional Names:
- C3c|Glomerulopathy, Kidney Disease, Lupus Nephritis, Infection, Sepsis, Inflammation, In Vitro Diagnostic
- Buffer:
- Frozen in PBS, pH 7.4
- CAS Number:
- 80295-41-6
- CE/IVD:
- RUO
- Extra Details:
- Complement C3c is a stable proteolytic fragment derived from complement component 3 (C3), the most abundant protein in the complement system (~1.2-1.5 mg/mL in plasma). C3 exists as a heterodimer comprising A Alpha (115 kDa) and B Beta (75 kDa) chains linked by disulfide bonds. Activation via classical, lectin, or alternative pathways cleaves C3 into C3a (anaphylatoxin) and C3b (opsonin), with C3b further processed by Factor I into iC3b and finally C3c (140 kDa) and C3d. Unlike transient C3b, C3c lacks covalent binding capacity, making it a soluble biomarker of complement activation. C3c quantification in plasma serves as a stable indicator of complement activation in conditions like sepsis and autoimmune diseases. Clinically, C3c assays aid in monitoring lupus and post-transplant rejection. Therapeutic C3 inhibitors (e.g., pegcetacoplan) target C3 cleavage to treat paroxysmal nocturnal hemoglobinuria and geographic atrophy, demonstrating broader potential in C3 glomerulopathy and age-related macular degeneration. Additionally, C3c's role in immune complex clearance informs drug development for autoimmune and inflammatory disorders.
- Formulation:
- Frozen in PBS, pH 7.4
- Molecular Weight:
- 138,000 Da
- Physical State:
- Frozen
- Purity:
- ≥95% Reacts to C3 antisera on Western Blot Negative against C4 antisera on Western Blot
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Dry Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
