Alpha 1 Acid Glycoprotein, Cynomolgus Monkey
Product Sizes
0.1 mg
16-16-010700-CM-0.1MG
About this Product
- SKU:
- 16-16-010700-CM
- Additional Names:
- A1AGP, AGP, AAG, Orosomucoid, ORM|Protein Glycosylation studies, In Vitro Diagnostics, Antisera Production
- Buffer:
- Salt-free lyophilized solid
- CE/IVD:
- RUO
- Extra Details:
- Alpha-1 acid glycoprotein (AGP), a glycoprotein constituting 55-140 mg/dL of plasma, features five N-linked glycan chains comprising 40-45% of its mass, including sialylated bi-/tri-/tetra-antennary structures critical for ligand interactions. Thus contributing to its use as a standard for glycosylation studies. As a major acute-phase reactant, AGP surges up to 5-fold during inflammation, synergizing with haptoglobin to diagnose acute inflammation and differentiate hepatic vs. obstructive jaundice. Its glycosylation profile shifts in pathologies: acute inflammation increases bi-antennary and A Alpha1,3-fucosylated glycans, while chronic states enhance tri-/tetra-antennary fucosylation. AGP binds progesterone 15x more avidly than albumin and complexes with vitamin B-12 when sialic acid-deficient, influencing drug pharmacokinetics and nutrient transport. AGP modulates immunity via TLR-2/4 interactions, exacerbating TLR-2-mediated sepsis mortality while inhibiting LPS-driven NETosis. Dysregulated AGP correlates with rheumatoid arthritis, Waldenstroem macroglobulinemia, and metastatic cancers, where glycoforms alter platelet aggregation and neutrophil adhesion. The AGP:haptoglobin ratio aids in diagnosing bone marrow disorders and hemolytic anemia, reflecting erythropoietic activityTherapeutically, AGP's drug-binding capacity informs personalized dosing for basic drugs (e.g., chlorpromazine), while engineered glycoforms are explored for targeted anti-inflammatory therapies.
- Formulation:
- Salt-free lyophilized solid
- Molecular Weight:
- 55,000 Da
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Cynomolgus Monkey plasma used to purify the Alpha 1 Acid Glycoprotein was obtained from healthy animals of US origin and under the care of a registered veterinarian. Prepared from donor monkeys that have been individually tested for B-Virus (Herpes Virus Simiae) and found to be negative
- Storage Conditions:
- -20[o]C
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
