Catalase
Product Sizes
0.5 mg
16-05-030000-0.5MG
50000 units
16-05-030000-50000UNITS
1 mg
16-05-030000-1MG
100000 units
16-05-030000-100000UNITS
5 mg
16-05-030000-5MG
About this Product
- SKU:
- 16-05-030000
- Additional Names:
- Cell Culture Media, Protein Chemistry Studies, Enzymatic Activity Assays|H2O2:H2O2 oxidoreductase, Catalase-peroxidase, CAT
- Application:
- Detection/Quantitation, Tissue Culture
- Buffer:
- Frozen in 50 mM Tris-HCl, pH 8.0.
- CAS Number:
- 9001-05-2
- CE/IVD:
- RUO
- Extra Details:
- Human catalase is a tetrameric enzyme composed of four identical subunits, each containing a heme group coordinated by tyrosine at the active site. This iron-dependent oxidoreductase catalyzes the rapid decomposition of hydrogen peroxide (2H2O2 to 2H2O+O2). Beyond its primary antioxidant role, catalase works with superoxide dismutase and glutathione peroxidase to neutralize reactive oxygen species (ROS), protecting cellular components from oxidative damage. Genetic mutations in the CAT gene cause acatalasemia, characterized by severe catalase deficiency (<10% activity) linked to oral ulcerations, gangrene, and heightened susceptibility to type 2 diabetes due to pancreatic B Beta-cell damage. Polymorphisms in catalase (e.g., -262 C/T promoter variant) correlate with oxidative stress-related pathologies, including hypertension, Alzheimer's disease, and vitiligo. Elevated catalase activity occurs in atherosclerosis and certain cancers as a compensatory response to chronic oxidative stress. Therapeutically, catalase is explored for treating ischemia-reperfusion injury through gene therapy and nanoparticle delivery systems. Recent clinical trials investigate catalase mimetics and combination antioxidant therapies for neurodegenerative disorders, leveraging its neuroprotective effects against amyloid-B Beta toxicity.
- Formulation:
- Frozen in 50 mM Tris-HCl, pH 8.0.
- Molecular Weight:
- 230 Kda
- Physical State:
- Frozen
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Dry Ice
- Source:
- Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
