Lipoprotein, Low Density, Oxidized (LDL-OX)
Product Sizes
5 mg
12-16-120412-OX-5MG
10 mg
12-16-120412-OX-10MG
About this Product
- SKU:
- 12-16-120412-OX
- Additional Names:
- Cell Culture Media, In Vitro Diagnostics, Assay Development, Cardiovascular Disease, Diabetes, Inflammation, Oxidative Stress|LDL-ox, oxLDL
- Application:
- Tissue Culture
- Buffer:
- Liquid in PBS +0.2mM EDTA, pH 7.4
- CE/IVD:
- RUO
- Extra Details:
- Oxidized low-density lipoprotein (Ox-LDL) is a modified form of LDL in which both the lipid and protein components, particularly apolipoprotein B-100, undergo oxidative changes. These modifications include the formation of aldehydes, cross-linking of amino acids, and the generation of new antigenic epitopes, making Ox-LDL structurally and functionally distinct from native LDL. Functionally, Ox-LDL is recognized and taken up by macrophage scavenger receptors, leading to foam cell formation-a key step in atherogenesis. Ox-LDL also acts as a cytotoxin, injuring endothelial cells, increasing endothelial permeability, and promoting inflammatory responses, which further contribute to vascular dysfunction and lesion development. Clinically, elevated levels of Ox-LDL are strongly associated with atherosclerosis, metabolic syndrome, type 2 diabetes, and coronary heart disease. Ox-LDL is implicated in the progression of these diseases due to its pro-inflammatory and cytotoxic effects on vascular cells. In research and diagnostics, Ox-LDL is used to study cellular responses to oxidative stress, to assess cardiovascular risk, and as a probe in assays such as ELISA, Western blot, and fluorescence microscopy to track its uptake and effects in biological systems.
- Formulation:
- Liquid in PBS +0.2mM EDTA, pH 7.4
- Molecular Weight:
- 2,300,000 Da
- Physical State:
- Liquid
- Purity:
- single arc by IEP against antisera to whole human serum. Essentially free of other plasma lipoproteins and chylomicrons as determined by electrophoresis using a SPIFE Vis Cholesterol gel kit for lipid
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
