Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Assay Kits & ELISAs

arigoPLEX[R] Human Fibrotic Marker Multiplex ELISA Kit (TGF beta 1, PDGF BB, IL6, TNF alpha)

Product Sizes
96 wells
ARG83353-96WELLS
Academic Pricing
Please contact us for academic pricing.
Contact us
About this Product
SKU:
ARG83353
Application:
ELISA
CE/IVD:
RUO
Conjugate:
HRP
Extra Details:
TGF beta 1:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]PDGF BB:This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]IL6:This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]TNF alpha:This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020]
Immunogen:
Fibrotic
Physical State:
Cell Culture Supernatant, Plasma, Serum
Reactivities:
Human
Sensitivity:
TGF beta1: 18.75 pg/mlPDGF BB: 7.8 pg/mlIL6: 7.8 pg/mlTNF alpha: 7.8 pg/ml
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C, -20[o]C
Supplier:
Arigo Biolaboratories
Type:
Assay Kits: ELISAs
ARG83353 arigoPLEX® Human Fibrotic Marker Multiplex ELISA Kit (TGF beta1, PDGF BB, IL6, TNF alpha) results of a typical standard for Human IL6 run with optical density reading at 450 nm.
ARG83353 arigoPLEX® Human Fibrotic Marker Multiplex ELISA Kit (TGF beta1, PDGF BB, IL6, TNF alpha) results of a typical standard for Human PDGF BB run with optical density reading at 450 nm.
ARG83353 arigoPLEX® Human Fibrotic Marker Multiplex ELISA Kit (TGF beta1, PDGF BB, IL6, TNF alpha) results of a typical standard for Human TGF beta1 run with optical density reading at 450 nm.
ARG83353 arigoPLEX® Human Fibrotic Marker Multiplex ELISA Kit (TGF beta1, PDGF BB, IL6, TNF alpha) results of a typical standard for Human TNF alpha run with optical density reading at 450 nm.