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Assay Kits & ELISAs

arigoPLEX[R] Human CAR-T / CRS Cytokine Multiplex ELISA Kit (IL2, IL6, IL10, IFN gamma)

Product Sizes
96 wells
ARG82969-96WELLS
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
ARG82969
Additional Names:
Human CAR-T / CRS Cytokine; CRS Cytokine ELISA Kit; CART Cytokine; Cytokine Release Syndrome Cytokine
Application:
ELISA
CE/IVD:
RUO
Conjugate:
HRP
Extra Details:
IL2:This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020]IL6:This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]IL10:The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]IFN gamma:This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Immunogen:
CAR-T / CRS
Physical State:
Cell Culture Supernatant, Plasma, Serum
Reactivities:
Human
Sensitivity:
IL2: 15.6 pg/mlIL6: 15.6 pg/mlIL10: 7.8 pg/mlIFN gamma: 7.8 pg/ml
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C, -20[o]C
Supplier:
Arigo Biolaboratories
Type:
Assay Kits: ELISAs
ARG82969 arigoPLEX® Human CAR-T / CRS Cytokine Multiplex ELISA Kit (IL2, IL6, IL10, IFN gamma) results of a typical standard for Human IL2 run with optical density reading at 450 nm.
ARG82969 arigoPLEX® Human CAR-T / CRS Cytokine Multiplex ELISA Kit (IL2, IL6, IL10, IFN gamma) results of a typical standard for Human IFN gamma run with optical density reading at 450 nm.
ARG82969 arigoPLEX® Human CAR-T / CRS Cytokine Multiplex ELISA Kit (IL2, IL6, IL10, IFN gamma) results of a typical standard for Human IL10 run with optical density reading at 450 nm.
ARG82969 arigoPLEX® Human CAR-T / CRS Cytokine Multiplex ELISA Kit (IL2, IL6, IL10, IFN gamma) results of a typical standard for Human IL6 run with optical density reading at 450 nm.