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Assay Kits & ELISAs

arigoPLEX[R] Mouse M1/M2 Cytokines Multiplex ELISA Kit (IL4, IL6, IL10, TNF alpha)

Product Sizes
96 wells
ARG82913-96WELLS
Academic Pricing
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About this Product
SKU:
ARG82913
Application:
ELISA
CE/IVD:
RUO
Conjugate:
HRP
Extra Details:
IL4:The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]IL6:This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]IL10:The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]TNF alpha:This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020]
Immunogen:
M1/M2 Cytokine
Physical State:
Cell Culture Supernatant, Plasma, Serum
Reactivities:
Mouse
References:
Extracellular vesicle-guided in situ reprogramming of synovial macrophages for the treatment of rheumatoid arthritis | Exploring the Hemostatic Effects of Platelet Lysate-Derived Vesicles: Insights from Mouse Models | Exploring the Hemostatic Effects of Platelet Lysate-Derived Vesicles: Insights from Mouse Models
Sensitivity:
IL4: 15.6 pg/mlIL6: 31.25 pg/mlIL10: 7.8 pg/mlTNF alpha: 15.6 pg/ml
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C, -20[o]C
Supplier:
Arigo Biolaboratories
Type:
Assay Kits: ELISAs
ARG82913 arigoPLEX® Mouse M1/M2 Cytokines multiplex ELISA Kit (IL4, IL6, IL10, TNF alpha) results of a typical standard for Mouse IL10 run with optical density reading at 450 nm.
ARG82913 arigoPLEX® Mouse M1/M2 Cytokines multiplex ELISA Kit (IL4, IL6, IL10, TNF alpha) results of a typical standard for Mouse IL4 run with optical density reading at 450 nm.
ARG82913 arigoPLEX® Mouse M1/M2 Cytokines multiplex ELISA Kit (IL4, IL6, IL10, TNF alpha) results of a typical standard for Mouse IL6 run with optical density reading at 450 nm.
ARG82913 arigoPLEX® Mouse M1/M2 Cytokines multiplex ELISA Kit (IL4, IL6, IL10, TNF alpha) results of a typical standard for Mouse TNF alpha run with optical density reading at 450 nm.